Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.69 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | PARG | Q86W56 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6890740 | 0.82 | GRM2 (1.00) | GRM2CREBBP | |
| SCHEMBL1503122 | 0.81 | ALDH1A1 (0.46) | GRM2PARGALDH1A1MAPTTSHR | |
| SCHEMBL1503038 | 0.80 | GRM2 (0.61) | GRM2PARGKMT2AMAPTNPSR1 | |
| SCHEMBL1502974 | 0.79 | GRM2 (0.64) | GRM2PARGALDH1A1MAPTNPSR1 | |
| SCHEMBL1502926 | 0.79 | GRM2 (0.64) | GRM2PARGALDH1A1MAPTNPSR1 | |
| SCHEMBL1502968 | 0.79 | GRM2 (0.64) | GRM2PARGALDH1A1MAPTNPSR1 | |
| SCHEMBL1503034 | 0.78 | GRM2 (0.46) | GRM2PARG | |
| SCHEMBL6891162 | 0.75 | GRM2 (0.50) | GRM2PARGMEN1KMT2AALDH1A1 | |
| SCHEMBL6891306 | 0.75 | GRM2 (0.52) | GRM2PARGKMT2AALDH1A1TSHR | |
| SCHEMBL6892255 | 0.75 | GRM2 (0.52) | GRM2PARGKMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |