SCHEMBL1502993 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	GRM2	Q14416	17/20	0.46

▸	ALDH1A1	P00352	1/20	0.33

▸	LMNA	P02545	1/20	0.33

▸	TSHR	P16473	1/20	0.33

▸	HTT	P42858	1/20	0.33

▸	CYP3A4	P08684	1/20	0.33

▸	MEN1	O00255	1/20	0.33

▸	GAA	P10253	1/20	0.33

▸	MAPT	P10636	1/20	0.33

▸	KMT2A	Q03164	1/20	0.33

▸	RXRA	P19793	1/20	0.31

▸	RXRB	P28702	1/20	0.31

▸	RXRG	P48443	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1503116	0.86	GRM2 (0.61)	GRM2CYP3A4
SCHEMBL1502949	0.86	GRM2 (0.61)	GRM2CYP3A4
SCHEMBL1503163	0.86	GRM2 (0.61)	GRM2CYP3A4
SCHEMBL6892790	0.81	GRM2 (0.45)	GRM2
SCHEMBL1503003	0.76	GRM2 (0.60)	GRM2CYP3A4
SCHEMBL1502937	0.69	GRM2 (0.69)	GRM2CYP3A4
SCHEMBL6890927	0.69	GRM2 (0.75)	GRM2CYP3A4
SCHEMBL1503034	0.69	GRM2 (0.46)	GRM2
SCHEMBL1503036	0.69	GRM2 (0.63)	GRM2CYP3A4
SCHEMBL1502995	0.68	GRM2 (0.60)	GRM2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011034741-A1	IMIDAZOPYRIDIN-2-ONE DERIVATIVES	MERCK SHARP & DOHME CORP. (US)	2011-03-24	—	—	WO	claimed