Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 7/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.40 |
| ▸ | ATR | Q13535 | 7/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 5/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16308183 | 0.90 | PDCD1 (0.40) | PDCD1CD274PIK3CBATRCHEK1 | |
| SCHEMBL15029933 | 0.90 | PIK3CB (0.45) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL17529091 | 0.88 | PDCD1 (0.40) | PDCD1CD274PIK3CBATRCHEK1 | |
| SCHEMBL16308170 | 0.88 | PDCD1 (0.42) | PDCD1CD274PIK3CBATRCHEK1 | |
| SCHEMBL16308179 | 0.88 | PDCD1 (0.43) | PDCD1CD274PIK3CBATRCHEK1 | |
| SCHEMBL15029787 | 0.88 | PDCD1 (0.45) | PDCD1CD274PIK3CBATRCHEK1 | |
| SCHEMBL16308182 | 0.85 | PDCD1 (0.40) | PDCD1CD274PIK3CBATRCHEK1 | |
| SCHEMBL15009420 | 0.84 | PDCD1 (0.40) | PDCD1CD274PIK3CBATRCHEK1 | |
| SCHEMBL15009424 | 0.84 | PDCD1 (0.40) | PDCD1CD274PIK3CBATRCHEK1 | |
| SCHEMBL16308152 | 0.84 | PDCD1 (0.41) | PDCD1CD274PIK3CBATRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130150364-A1 | HETEROCYCLIC COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150364-A1 | HETEROCYCLIC COMPOUND | IL2, NFATC1, ICOS | PDCD1 285/4885CD274 453/4885PIK3CB 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.