Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 7/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.42 |
| ▸ | ATR | Q13535 | 6/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 5/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 8/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15029298 | 0.91 | PDCD1 (0.53) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL15029297 | 0.91 | PDCD1 (0.53) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL15029348 | 0.90 | PIK3CB (0.46) | PIK3CBPIK3CAPIK3R1PIK3CDHTR4 | |
| SCHEMBL16308179 | 0.89 | PDCD1 (0.43) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL15029787 | 0.89 | PDCD1 (0.45) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL15029967 | 0.88 | PDCD1 (0.43) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL16308152 | 0.85 | PDCD1 (0.41) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL10125162 | 0.85 | PDCD1 (0.53) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL10125164 | 0.85 | PDCD1 (0.53) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL16308183 | 0.84 | PDCD1 (0.40) | PDCD1CD274ATRCHEK1ATRIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604601-B1 | HETERO RING COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-02-24 | — | — | EP | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |