Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 4/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.38 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 4/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16308130 | 0.92 | PDCD1 (0.49) | PDCD1CD274PIK3CBPIK3CACHEK1 | |
| SCHEMBL16308099 | 0.92 | PDCD1 (0.49) | PDCD1CD274PIK3CBPIK3CACHEK1 | |
| SCHEMBL16308155 | 0.91 | TGFBR1 (0.42) | PIK3CBBCDIN3DTGFBR1PIK3R1PIK3CA | |
| SCHEMBL15029967 | 0.90 | PDCD1 (0.43) | PDCD1CD274PIK3CBPIK3R1PIK3CA | |
| SCHEMBL16308182 | 0.90 | PDCD1 (0.40) | PDCD1CD274PIK3CBPIK3R1PIK3CA | |
| SCHEMBL17529091 | 0.89 | PDCD1 (0.40) | PDCD1CD274PIK3CBPIK3R1PIK3CA | |
| SCHEMBL16308100 | 0.85 | PIK3CB (0.46) | PDCD1CD274PIK3CBPIK3R1PIK3CA | |
| SCHEMBL16308132 | 0.85 | PIK3CB (0.46) | PDCD1CD274PIK3CBBCDIN3DPIK3R1 | |
| SCHEMBL16308131 | 0.85 | PIK3CB (0.46) | PDCD1CD274PIK3CBPIK3CAPIK3CD | |
| SCHEMBL16308170 | 0.84 | PDCD1 (0.42) | PDCD1CD274PIK3CBPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |