Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13222426 | 1.00 | DRD2 (0.47) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL3194532 | 0.92 | MEN1 (0.50) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL13481957 | 0.92 | MEN1 (0.50) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL3026950 | 0.89 | DRD2 (0.53) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL3026936 | 0.89 | DRD2 (0.53) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL13481940 | 0.87 | DRD2 (0.49) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL13222423 | 0.86 | MAPT (0.38) | DRD2MEN1KMT2AALDH1A1HTR1A | |
| SCHEMBL13222462 | 0.82 | DRD2 (0.47) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL13222400 | 0.82 | DRD2 (0.47) | DRD2DRD4DRD3MEN1KMT2A | |
| Oxalic Acid SCHEMBL3026945 | 0.81 | DRD2 (0.52) | DRD2DRD4DRD3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466296-B2 | Compounds and processes for preparing substituted aminomethyl-2,3,8,9-tetrahydro-7H-1,4-dioxino[2,3-e]indol-8-ones | LIGAND PHARMACEUTICALS (US) | 2013-06-18 | — | — | US | disclosed |