Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
| ▸ | CDC25A | P30304 | 1/20 | 0.49 |
| ▸ | CDC25B | P30305 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL357669 | 0.82 | CYP3A4 (0.72) | CYP3A4CYP2C9KMT2AAKR1C3ALDH1A1 | |
| SCHEMBL31696155 | 0.82 | MAPT (0.63) | CYP3A4CYP2C9GSTA1MAPK13MAPK12 | |
| SCHEMBL8785629 | 0.81 | ALDH1A1 (0.64) | CYP3A4CYP2C9KMT2AAKR1C3ALDH1A1 | |
| SCHEMBL4676503 | 0.80 | CDC25B (0.55) | KMT2AAKR1C3ALDH1A1GSTA1CDC25B | |
| SCHEMBL4704774 | 0.80 | MAPT (0.69) | CYP2C9SORT1AKR1C3ALDH1A1CDC25A | |
| SCHEMBL17332 | 0.79 | KDM4E (0.59) | CYP2C9KMT2ASORT1MYCNR4A1 | |
| SCHEMBL29571243 | 0.79 | KDM4E (0.59) | CYP2C9KMT2ASORT1MYCNR4A1 | |
| SCHEMBL10669335 | 0.78 | CYP3A4 (0.59) | CYP3A4CYP2C9KMT2AALDH1A1MAPK13 | |
| SCHEMBL10731388 | 0.78 | KMT2A (0.50) | CYP3A4CYP2C9KMT2AAKR1C3ALDH1A1 | |
| SCHEMBL5153378 | 0.77 | CDC25B (0.48) | CYP2C9SORT1ALDH1A1CDC25BHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012443-B2 | Bicyclic aryl and heteroaryl sodium channel inhibitors | AMGEN INC. (US) | 2015-04-21 | — | — | US | disclosed |
| US-20130150339-A1 | Bicyclic Aryl and Heteroaryl Sodium Channel Inhibitors | AMGEN INC. (US) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150339-A1 | Bicyclic Aryl and Heteroaryl Sodium Channel Inhibitors | SCN1A, SCN1B, CACNA1B | CYP3A4 539/4885CYP2C9 218/4885KMT2A 1920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.