Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503183 | 0.79 | NAMPT (0.39) | — | |
| SCHEMBL2216328 | 0.78 | EGFR (0.41) | HDAC6HDAC3HDAC8HDAC1HDAC11 | |
| SCHEMBL2146957 | 0.77 | HDAC6 (0.37) | HDAC6HDAC3HDAC8HDAC1HDAC2 | |
| SCHEMBL30954811 | 0.76 | MMP1 (0.39) | EGLN1 | |
| SCHEMBL1503250 | 0.76 | MMP1 (0.39) | EGLN1 | |
| SCHEMBL1503241 | 0.76 | HDAC1 (0.39) | HDAC6HDAC3HDAC8HDAC1HDAC2 | |
| SCHEMBL1503199 | 0.76 | ALDH1A1 (0.35) | HDAC6HDAC3HDAC8HDAC1HDAC2 | |
| SCHEMBL1503231 | 0.75 | ALDH1A1 (0.42) | HDAC6HDAC3HDAC1HDAC2EGLN2 | |
| SCHEMBL1503246 | 0.75 | EGFR (0.36) | HDAC6HDAC3HDAC8HDAC1HDAC2 | |
| SCHEMBL12516709 | 0.74 | HDAC1 (0.43) | HDAC6HDAC3HDAC8HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300433-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | Ambrilia Biopharma Inc. (CA) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009146555-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | AMBRILIA BIOPHARMA INC. (CA) | 2009-12-10 | — | — | WO | disclosed |