⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19138056 | 0.74 | ALDH1A1 (0.44) | — | |
| SCHEMBL51408 | 0.72 | — | — | |
| SCHEMBL28562323 | 0.70 | ALDH1A1 (0.41) | — | |
| SCHEMBL22612036 | 0.70 | — | — | |
| SCHEMBL28830723 | 0.70 | — | — | |
| Water SCHEMBL15210122 | 0.70 | ALDH1A1 (0.41) | — | |
| Water SCHEMBL3454746 | 0.70 | ALDH1A1 (0.41) | — | |
| SCHEMBL1703143 | 0.70 | — | — | |
| SCHEMBL686972 | 0.70 | — | — | |
| SCHEMBL644095 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3045449-A1 | TETRACYCLINE DERIVATIVES FOR THE TREATMENT OF BACTERIAL, VIRAL AND PARASITIC INFECTIONS | Paratek Pharmaceuticals, Inc. (US) | 2016-07-20 | — | — | EP | disclosed |
| EP-2450347-B1 | Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections | PARATEK PHARM INNC (US) | 2015-06-24 | — | — | EP | disclosed |
| EP-2109602-B1 | TETRACYCLINE DERIVATIVES FOR THE TREATMENT OF BACTERIAL, VIRAL AND PARASITIC INFECTIONS | PARATEK PHARM INNC (US) | 2014-02-12 | — | — | EP | disclosed |
| US-8466132-B2 | Bactericides; antitumor agents; modulation of gene expression; malaria therapy; viricides; parasiticides; multiple sclerosis | PARATEK PHARMACEUTICALS, INC. (US) | 2013-06-18 | — | — | US | disclosed |