Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 8/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503632 | 0.87 | ADAM17 (0.63) | ADAM17HTTADAM10MMP3GPR132 | |
| SCHEMBL1503502 | 0.83 | ADAM17 (0.87) | ADAM17HTTADAM10HDAC1MMP3 | |
| SCHEMBL1503671 | 0.83 | ADAM17 (0.87) | ADAM17HTTADAM10HDAC1MMP3 | |
| SCHEMBL1503640 | 0.80 | ADAM17 (0.81) | ADAM17HTTADAM10HDAC1MMP3 | |
| SCHEMBL1503664 | 0.80 | ADAM17 (0.52) | ADAM17GRM5MRGPRX4 | |
| SCHEMBL1503517 | 0.79 | ADAM17 (1.00) | ADAM17HTTADAM10MMP3MMP1 | |
| SCHEMBL12076822 | 0.79 | ADAM17 (1.00) | ADAM17HTTADAM10MMP3MMP1 | |
| SCHEMBL1503525 | 0.78 | ADAM17 (0.66) | ADAM17ADAM10MMP3MMP1 | |
| SCHEMBL1504776 | 0.75 | ADAM17 (0.63) | ADAM17ADAM10HDAC1MMP3MMP1 | |
| SCHEMBL1503535 | 0.74 | TP53 (0.43) | ADAM17TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033010-A1 | 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |