Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ASAH2 | Q9NR71 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503648 | 0.81 | ADAM17 (0.59) | TP53NPSR1KDM4EADAM17KMT2A | |
| SCHEMBL10475842 | 0.80 | ADAM17 (0.55) | TP53KDM4ELMNAADAM17 | |
| SCHEMBL10475882 | 0.80 | ADAM17 (0.55) | TP53KDM4ELMNAADAM17 | |
| SCHEMBL1503521 | 0.78 | ALDH1A1 (0.47) | TP53KDM4EMEN1KMT2A | |
| SCHEMBL1503632 | 0.76 | ADAM17 (0.63) | HRH3ADAM17MEN1KMT2A | |
| SCHEMBL1503675 | 0.76 | ADAM17 (0.55) | TP53LMNAADAM17 | |
| SCHEMBL1503620 | 0.76 | ADAM17 (0.55) | TP53LMNAADAM17 | |
| SCHEMBL1503525 | 0.74 | ADAM17 (0.66) | ADAM17 | |
| SCHEMBL1503522 | 0.74 | ADAM17 (0.65) | TP53ADAM17 | |
| SCHEMBL1503623 | 0.71 | ALDH1A1 (0.46) | TP53HRH3KDM4ECTNNB1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033010-A1 | 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |