Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 16/20 | 0.65 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10475836 | 0.93 | ADAM17 (0.68) | ADAM17ADAM10MMP3MMP1HTT | |
| SCHEMBL10475832 | 0.93 | ADAM17 (0.68) | ADAM17ADAM10MMP3MMP1HTT | |
| SCHEMBL1503484 | 0.92 | ADAM17 (0.77) | ADAM17ADAM10MMP3MMP1 | |
| SCHEMBL1503486 | 0.92 | ADAM17 (0.77) | ADAM17ADAM10MMP3MMP1 | |
| SCHEMBL1503664 | 0.82 | ADAM17 (0.52) | ADAM17MRGPRX4RAF1BRAF | |
| SCHEMBL1503586 | 0.81 | ADAM17 (0.51) | ADAM17MRGPRX4RAF1BRAF | |
| SCHEMBL1503546 | 0.81 | ADAM17 (0.79) | ADAM17ADAM10MMP3ATM | |
| SCHEMBL1503640 | 0.79 | ADAM17 (0.81) | ADAM17ADAM10MMP3MMP1HTT | |
| SCHEMBL1503562 | 0.79 | ADAM17 (1.00) | ADAM17ADAM10MMP3MMP1 | |
| SCHEMBL1503556 | 0.79 | ADAM17 (1.00) | ADAM17ADAM10MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033010-A1 | 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |