Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10475832 | 0.83 | ADAM17 (0.68) | ADAM17RAF1BRAFMEN1KMT2A | |
| SCHEMBL10475836 | 0.83 | ADAM17 (0.68) | ADAM17RAF1BRAFMEN1KMT2A | |
| SCHEMBL1503584 | 0.81 | ADAM17 (0.65) | ADAM17RAF1BRAFMRGPRX4 | |
| SCHEMBL1503561 | 0.81 | ADAM17 (0.58) | ADAM17ALDH1A1MAPK14MEN1KMT2A | |
| SCHEMBL1503484 | 0.81 | ADAM17 (0.77) | ADAM17 | |
| SCHEMBL1503486 | 0.81 | ADAM17 (0.77) | ADAM17 | |
| SCHEMBL1503664 | 0.80 | ADAM17 (0.52) | ADAM17ALDH1A1RAF1BRAFPOLB | |
| SCHEMBL12077180 | 0.74 | ADAM17 (0.60) | ADAM17ALDH1A1CYP4F2CYP4A11HDAC1 | |
| SCHEMBL1503540 | 0.71 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2A | |
| SCHEMBL1503650 | 0.71 | ALDH1A1 (0.59) | ALDH1A1POLBKMT2ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033010-A1 | 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |