Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 11/20 | 0.56 |
| ▸ | MMP13 | P45452 | 2/20 | 0.52 |
| ▸ | MMP9 | P14780 | 2/20 | 0.52 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503703 | 1.00 | ADAM17 (0.56) | ADAM17MMP13MMP9ADAM10MMP3 | |
| SCHEMBL10475829 | 0.91 | ADAM17 (0.57) | ADAM17MMP13MMP9ADAM10MMP3 | |
| SCHEMBL10475830 | 0.91 | ADAM17 (0.57) | ADAM17MMP13MMP9ADAM10MMP3 | |
| SCHEMBL1504705 | 0.77 | ADAM17 (0.60) | ADAM17MMP13MMP9ADAM10MMP3 | |
| SCHEMBL1503702 | 0.75 | ADAM17 (0.52) | ADAM17MMP13MMP9ADAM10MMP3 | |
| SCHEMBL1503594 | 0.74 | ADAM17 (0.81) | ADAM17ADAM10MMP3ADAM9 | |
| SCHEMBL1503646 | 0.74 | ADAM17 (0.81) | ADAM17ADAM10MMP3ADAM9 | |
| SCHEMBL1503704 | 0.73 | ADAM17 (0.49) | ADAM17MMP13MMP9ADAM10MMP3 | |
| SCHEMBL5527570 | 0.72 | CTSL (0.53) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1503492 | 0.72 | ADAM17 (1.00) | ADAM17ADAM10MMP3ADAM9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033010-A1 | 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |