Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP17A1 | P05093 | 10/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | QDPR | P09417 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628639 | 0.84 | — | — | |
| SCHEMBL679947 | 0.84 | HRH3 (0.47) | LMNACYP17A1CYP11B1CYP11B2CYP3A4 | |
| Hydrochloric Acid SCHEMBL17654197 | 0.81 | — | — | |
| SCHEMBL5226620 | 0.80 | MAPT (0.55) | MAPTLMNACYP17A1CYP11B1CYP11B2 | |
| SCHEMBL10000032 | 0.78 | MAPT (0.92) | MAPTLMNACYP3A4NOTUMKIF11 | |
| SCHEMBL135626 | 0.78 | MAPT (0.92) | MAPTLMNACYP3A4NOTUMKIF11 | |
| SCHEMBL19567238 | 0.76 | CYP2A6 (0.67) | MAPTLMNACYP17A1CYP11B1CYP11B2 | |
| SCHEMBL1129630 | 0.75 | MAPT (0.55) | MAPTLMNACYP17A1CYP11B1CYP11B2 | |
| SCHEMBL8239917 | 0.75 | MAPT (0.59) | MAPTLMNACYP17A1CYP11B1CYP11B2 | |
| SCHEMBL1439245 | 0.75 | MKNK1 (0.61) | MAPTLMNACYP17A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604269-A1 | 1,4-benzodiazepine-2,5-diones with therapeutic properties | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-06-19 | — | — | EP | disclosed |