Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15038351 | 0.83 | CLK4 (0.52) | LMNAMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL15038352 | 0.80 | ADORA2A (0.49) | LMNAMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL26242537 | 0.78 | MAPT (0.43) | LMNAMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL15038353 | 0.77 | KMT2A (0.45) | MAPTSMN1; SMN2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL15038312 | 0.77 | NPC1 (0.45) | SMN1; SMN2ALDH1A1KDM4EHPGDMAPK14 | |
| SCHEMBL15038380 | 0.73 | ALDH1A1 (0.47) | MAPTSMN1; SMN2ALDH1A1HSD17B10HPGD | |
| SCHEMBL28323441 | 0.72 | KDM4E (0.38) | SMN1; SMN2KDM4EHPGDMAPK14MAPK11 | |
| SCHEMBL9775493 | 0.72 | KDM4E (0.58) | LMNAMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL27976843 | 0.72 | ADORA2A (0.47) | LMNAMAPTKDM4EHSD17B10MAPK1 | |
| SCHEMBL15038415 | 0.71 | ADORA2A (0.53) | ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318389-B1 | PYRIDAZINE DERIVATIVES AS SMO INHIBITORS | NOVARTIS AG (CH) | 2013-06-19 | — | — | EP | disclosed |