Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | GLA | P06280 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220198 | 0.73 | KMT2A (0.51) | KMT2AALDH1A1GAAMEN1SMN1; SMN2 | |
| SCHEMBL10855053 | 0.68 | CYP3A4 (0.50) | KMT2AALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL220200 | 0.68 | KMT2A (0.57) | KMT2AALDH1A1GAAMEN1SMN1; SMN2 | |
| SCHEMBL7258678 | 0.66 | KMT2A (0.40) | KMT2AMEN1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL3297433 | 0.66 | KMT2A (0.54) | KMT2AALDH1A1GAAMEN1SMN1; SMN2 | |
| SCHEMBL3472829 | 0.66 | ALDH1A1 (0.55) | KMT2AALDH1A1GAAMEN1SMN1; SMN2 | |
| SCHEMBL319866 | 0.66 | KMT2A (0.73) | KMT2AALDH1A1MEN1SMN1; SMN2KDM4E | |
| SCHEMBL16322281 | 0.65 | KMT2A (0.57) | KMT2AALDH1A1GAAMEN1SMN1; SMN2 | |
| SCHEMBL29451951 | 0.65 | KMT2A (0.53) | KMT2AALDH1A1GAAMEN1SMN1; SMN2 | |
| SCHEMBL16644078 | 0.65 | KMT2A (0.53) | KMT2AALDH1A1GAAMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604260-B1 | NOVEL HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | SHIONOGI & CO (JP) | 2017-05-10 | — | — | EP | disclosed |
| EP-2604260-A1 | NOVEL HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Shionogi&Co., Ltd. (JP) | 2013-06-19 | — | — | EP | disclosed |