Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GNRHR | P30968 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15040035 | 0.86 | ATM (0.50) | TSHRALDH1A1NPSR1MAPTHTT | |
| SCHEMBL15039615 | 0.85 | TSHR (0.58) | TSHRTP53P2RX3 | |
| SCHEMBL15015797 | 0.82 | TSHR (0.55) | TSHRTP53ALDH1A1NPSR1MAPT | |
| SCHEMBL9983069 | 0.82 | P2RX3 (0.57) | TSHRP2RX3 | |
| SCHEMBL15015978 | 0.80 | TSHR (0.53) | TSHRTP53ALDH1A1NPSR1MAPT | |
| SCHEMBL15039888 | 0.79 | TSHR (0.49) | TSHRTP53ALDH1A1NPSR1MAPT | |
| SCHEMBL15039803 | 0.78 | TSHR (0.51) | TSHRALDH1A1NPSR1MAPTHTT | |
| SCHEMBL15015852 | 0.78 | TSHR (0.56) | TSHRTP53ALDH1A1NPSR1MAPT | |
| SCHEMBL15015572 | 0.77 | TSHR (0.53) | TSHRTP53ALDH1A1NPSR1MAPT | |
| SCHEMBL10056322 | 0.77 | P2RX3 (0.52) | TSHRP2RX3TBXA2RDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604595-A1 | TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOUND THAT CONTAINS SAME AND EXHIBITS ANALGESIC ACTIVITY | Shionogi&Co., Ltd. (JP) | 2013-06-19 | — | — | EP | disclosed |