Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 7/20 | 0.78 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.78 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL436150 | 0.87 | S1PR1 (1.00) | S1PR1S1PR5ALOX15HDAC4HDAC1 | |
| SCHEMBL29389224 | 0.87 | S1PR1 (1.00) | S1PR1S1PR5ALOX15HDAC4HDAC1 | |
| SCHEMBL14327877 | 0.80 | SMN1; SMN2 (0.60) | S1PR1S1PR5ALOX15NPSR1NPC1 | |
| SCHEMBL14327901 | 0.78 | S1PR1 (0.57) | S1PR1S1PR5ALOX15NPSR1NPC1 | |
| SCHEMBL29695849 | 0.78 | S1PR1 (0.82) | S1PR1S1PR5ALOX15HDAC4HDAC1 | |
| SCHEMBL14327879 | 0.78 | ALDH1A1 (0.56) | S1PR1S1PR5ALOX15NR1H4NPSR1 | |
| SCHEMBL5953007 | 0.78 | S1PR1 (0.51) | S1PR1S1PR5ALOX15HDAC4HDAC1 | |
| SCHEMBL13416529 | 0.77 | S1PR1 (1.00) | S1PR1S1PR5ALOX15HDAC4HDAC1 | |
| SCHEMBL28537555 | 0.76 | HDAC6 (0.67) | S1PR1S1PR5ALOX15HDAC4HDAC1 | |
| SCHEMBL13930792 | 0.76 | CASP3 (0.65) | S1PR1S1PR5ALOX15HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9763980-B2 | Combined chemical modification of sphingosine-1-phosphate (S1P) and CXCR4 signalling pathways for hematopoietic stem cell (HSC) mobilization and engraftment | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2017-09-19 | — | — | US | disclosed |
| US-20170216356-A1 | IMMUNOTHERAPY USING REDIRECTED ALLOGENEIC CELLS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2017-08-03 | — | — | US | disclosed |
| US-9623049-B2 | Immunotherapy using redirected allogeneic cells | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2017-04-18 | — | — | US | disclosed |
| US-20140193376-A1 | COMBINED CHEMICAL MODIFICATION OF SPHINGOSINE-1-PHOSPHATE (S1P) AND CXCR4 SIGNALLING PATHWAYS FOR HEMATOPOIETIC STEM CELL (HSC) MOBILIZATION AND ENGRAFTMENT | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2014-07-10 | — | — | US | disclosed |
| US-20130156794-A1 | IMMUNOTHERAPY USING REDIRECTED ALLOGENEIC CELLS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140193376-A1 | COMBINED CHEMICAL MODIFICATION OF SPHINGOSINE-1-PHOSPHATE (S1P) AND CXCR4 SIGNALLING PATHWAYS FOR HEMATOPOIETIC STEM CELL (HSC) MOBILIZATION AND ENGRAFTMENT | S1PR1, S1PR4, S1PR3 | S1PR1 1/4885S1PR5 5/4885ALOX15 2523/4885 |
| US-20130156794-A1 | IMMUNOTHERAPY USING REDIRECTED ALLOGENEIC CELLS | CD47, CD69, ICOS | S1PR1 150/4885S1PR5 161/4885ALOX15 1876/4885 |
| US-20170216356-A1 | IMMUNOTHERAPY USING REDIRECTED ALLOGENEIC CELLS | CD47, CD69, ICOS | S1PR1 150/4885S1PR5 161/4885ALOX15 1876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.