Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 8/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.32 |
| ▸ | CDK1 | P06493 | 7/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12294482 | 0.79 | KDM4E (0.36) | HPGDGFERHSD17B10GSK3BKIF11 | |
| SCHEMBL17973035 | 0.74 | CYP17A1 (0.34) | HPGDGFERHSD17B10GSK3BKDM4E | |
| SCHEMBL15042860 | 0.74 | HPGD (0.37) | MEN1KMT2AHPGDGFERHSD17B10 | |
| SCHEMBL2707318 | 0.72 | KDM4E (0.35) | HPGDGFERHSD17B10KDM4ELMNA | |
| SCHEMBL12294490 | 0.72 | HSD17B10 (0.37) | HPGDGFERHSD17B10KDM4ELMNA | |
| SCHEMBL15045555 | 0.71 | GSK3B (0.44) | HSD17B10SMN1; SMN2GSK3BCCNB2CDK1 | |
| SCHEMBL15042845 | 0.71 | NPSR1 (0.33) | MEN1KMT2AHPGDGFERHSD17B10 | |
| SCHEMBL15042912 | 0.70 | MEN1 (0.37) | MEN1KMT2AHPGDGFERHSD17B10 | |
| SCHEMBL10118796 | 0.70 | PSMB5 (0.36) | HPGDGFERHSD17B10KDM4ELMNA | |
| SCHEMBL10118798 | 0.70 | KDM4E (0.36) | HPGDGFERHSD17B10SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796705-B2 | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases | MERCK SHARP & DOHME CORP. (US) | 2017-10-24 | — | — | US | disclosed |
| US-20170008879-A1 | FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2017-01-12 | — | — | US | disclosed |
| US-20130156731-A1 | FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEAS | SCHERING CORPORATION | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130156731-A1 | FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEAS | HAVCR2, ELOC, ZC3HAV1 | MEN1 2525/4885KMT2A 1061/4885HPGD 984/4885 |
| US-20170008879-A1 | FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | ZC3HAV1, HAVCR2, ZC3HAV1L | MEN1 2324/4885KMT2A 1933/4885HPGD 3077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.