ELOC — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15110355	0.83	15/20
SCHEMBL15112002	0.83	15/20
SCHEMBL15110402	0.79	14/20
SCHEMBL15110438	0.75	14/20
SCHEMBL15110445	0.75	14/20
SCHEMBL15110331	0.57	13/20
SCHEMBL15110221	0.56	13/20
SCHEMBL15110257	0.80	12/20
SCHEMBL15110329	0.79	12/20
SCHEMBL15112608	0.79	12/20
SCHEMBL15110281	0.74	12/20
SCHEMBL15112677	0.70	12/20
SCHEMBL15125829	0.70	12/20
SCHEMBL15112661	0.65	12/20
SCHEMBL15110112	0.64	12/20
SCHEMBL15110424	0.61	12/20
SCHEMBL15110391	0.60	12/20
SCHEMBL15110317	0.54	12/20
SCHEMBL15110166	0.49	12/20
SCHEMBL15110047	0.47	12/20

Clinical trials — most relevant to ELOC by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Phase Ib/II Clinical Study Evaluating the Safety and Efficacy of Tislelizumab in Combination With Golidocitinib and Selinexor for the Treatment of R/R NKTCL	PHASE1/PHASE2	RECRUITING
Tianasen (ASO-GNAO1) for GNAO1-Encephalopathy With Epilepsy and Movement Disorders.	PHASE1/PHASE2	RECRUITING
Phase II Study of Vandetanib in Individuals With Kidney Cancer	PHASE2	COMPLETED
EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment	PHASE2	COMPLETED
Sirolimus Treatment in Patients With Autosomal Dominant Polycystic Kidney Disease: Renal Efficacy and Safety	PHASE2	COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors	nan	COMPLETED
MEHMO Natural History and Biomarkers	nan	RECRUITING
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Research on the Early and Prognosis Diagnosis of Vascular Dementia	nan	RECRUITING
Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks	nan	RECRUITING
Impact of Elastin Mediated Vascular Stiffness on End Organs	nan	COMPLETED
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
Biomarkers in Samples of Bone Marrow From Patients With Acute Myeloid Leukemia	nan	COMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Non-invasive Prognostication of COVID-19 Patients by Use of Biomarkers in Exhaled Breath Condensate	nan	COMPLETED
Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank	nan	COMPLETED
Genomic Translation for Amyotrophic Lateral Sclerosis Care	nan	COMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics	nan	UNKNOWN
Phenotypic and Genotypic Characterization of Subjects With Syndromic Obesity: Identifying New Candidate Genes by Exome Sequencing (OBEXOME)	nan	COMPLETED
Novel Strategy for Early Detection of Esophageal Squamous Cell Carcinoma	nan	RECRUITING
Corpus Callosum Agenesis and Intellectual Disability	nan	COMPLETED
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis	nan	UNKNOWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population	nan	COMPLETED
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases	nan	NOT_YET_RECRUITING
Mutational Landscape in Hepatocellular Carcinoma	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ELOC binder may also engage these)

Protein	Name	Similarity
Q2KII4	—	1.000	Q2KII4 →
P83941	—	1.000	P83941 →
P83940	—	1.000	P83940 →
Q9USX9	—	0.971	Q9USX9 →
Q03071	—	0.971	Q03071 →
B8NSJ0	—	0.968	B8NSJ0 →
Q54Q05	—	0.968	Q54Q05 →
B6QGB9	—	0.968	B6QGB9 →
Q8TGW7	—	0.967	Q8TGW7 →
Q8NK13	—	0.966	Q8NK13 →
Q9Y709	—	0.966	Q9Y709 →
Q5KU00	—	0.966	Q5KU00 →
Q0CA59	—	0.966	Q0CA59 →
Q751F9	—	0.965	Q751F9 →
Q4WTT8	—	0.965	Q4WTT8 →
Q6H4D6	—	0.965	Q6H4D6 →
Q9FHW7	—	0.963	Q9FHW7 →
G5ECU1	—	0.963	G5ECU1 →
D4ARL8	—	0.962	D4ARL8 →
Q9LNT9	—	0.962	Q9LNT9 →
Q557E4	—	0.962	Q557E4 →
O65674	—	0.962	O65674 →
A1CZG3	—	0.961	A1CZG3 →
B0Y3B5	—	0.961	B0Y3B5 →
A1C9U5	—	0.961	A1C9U5 →
B8MDP8	—	0.960	B8MDP8 →
Q6PL11	—	0.960	Q6PL11 →
Q96Q07	—	0.959	Q96Q07 →
Q5BAX8	—	0.959	Q5BAX8 →
Q651E8	—	0.959	Q651E8 →