Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.36 |
| ▸ | CDK1 | P06493 | 7/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.36 |
| ▸ | GSK3B | P49841 | 7/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15042912 | 0.80 | MEN1 (0.37) | HPGDGFERHSD17B10MEN1KMT2A | |
| SCHEMBL15042852 | 0.79 | LMNA (0.38) | HPGDGFERHSD17B10KMT2AKDM4E | |
| SCHEMBL2607637 | 0.77 | AHR (0.56) | HPGDGFERHSD17B10MEN1KMT2A | |
| SCHEMBL15042818 | 0.74 | MEN1 (0.35) | HPGDGFERHSD17B10MEN1KMT2A | |
| SCHEMBL2611053 | 0.74 | AHR (0.56) | HPGDGFERHSD17B10MEN1KMT2A | |
| SCHEMBL15042840 | 0.73 | HPGD (0.42) | HPGDGFERHSD17B10KDM4EKIF11 | |
| SCHEMBL13560743 | 0.73 | LMNA (0.38) | HPGDGFERHSD17B10MEN1KMT2A | |
| SCHEMBL15042870 | 0.71 | KDM4E (0.35) | HPGDGFERHSD17B10MEN1KMT2A | |
| SCHEMBL22525923 | 0.71 | TDP2 (0.58) | HPGDGFERHSD17B10 | |
| SCHEMBL15045451 | 0.70 | GSK3B (0.46) | HSD17B10CCNB2CDK1CCNB1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796705-B2 | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases | MERCK SHARP & DOHME CORP. (US) | 2017-10-24 | — | — | US | disclosed |
| US-20170008879-A1 | FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2017-01-12 | — | — | US | disclosed |
| US-20130156731-A1 | FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEAS | SCHERING CORPORATION | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130156731-A1 | FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEAS | HAVCR2, ELOC, ZC3HAV1 | HPGD 984/4885GFER 2397/4885HSD17B10 230/4885 |
| US-20170008879-A1 | FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | ZC3HAV1, HAVCR2, ZC3HAV1L | HPGD 3077/4885GFER 4725/4885HSD17B10 615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.