SCHEMBL150437

SCHEMBL150437

Nc1cccc2c(Br)cccc12

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.68
HPGD P15428 3/20 0.68
CYP3A4 P08684 3/20 0.68
TSHR P16473 2/20 0.68
HSD17B10 Q99714 2/20 0.68
TDP1 Q9NUW8 2/20 0.68
NR4A2 P43354 1/20 0.52
KEAP1 Q14145 2/20 0.50
MEN1 O00255 3/20 0.48
MAPT P10636 3/20 0.48
KMT2A Q03164 3/20 0.48
KDM4E B2RXH2 2/20 0.48
IDO1 P14902 2/20 0.48
TDP2 O95551 2/20 0.48
USP2 O75604 1/20 0.48
POLB P06746 1/20 0.48
TDO2 P48775 1/20 0.48
BLM P54132 1/20 0.48
CASP6 P55212 1/20 0.48
SAE1 Q9UBE0 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29813552 1.00 ALDH1A1 (0.68) ALDH1A1HPGDCYP3A4TSHRHSD17B10
SCHEMBL28868145 0.95 ALDH1A1 (0.62) ALDH1A1HPGDCYP3A4TSHRHSD17B10
SCHEMBL30065419 0.84 AXL (0.54) ALDH1A1HPGDCYP3A4TSHRHSD17B10
SCHEMBL295976 0.84 AXL (0.54) ALDH1A1HPGDCYP3A4TSHRHSD17B10
SCHEMBL1489217 0.83 PARP1 (0.54) ALDH1A1HPGDCYP3A4TSHRHSD17B10
SCHEMBL48843 0.83 ALDH1A1 (1.00) ALDH1A1HPGDCYP3A4TSHRHSD17B10
SCHEMBL29375428 0.83 PARP1 (0.54) ALDH1A1HPGDCYP3A4TSHRHSD17B10
SCHEMBL29365003 0.83 ALDH1A1 (1.00) ALDH1A1HPGDCYP3A4TSHRHSD17B10
SCHEMBL17035155 0.81 ALDH1A1 (0.56) ALDH1A1HPGDCYP3A4TSHRHSD17B10
SCHEMBL335367 0.80 ALDH1A1 (0.93) ALDH1A1HPGDCYP3A4TSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 191 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117903013-A Preparation method of organic luminescent material intermediate 8-bromophenanthrene-1-trifluoromethanesulfonate 奥盖尼克材料(苏州)有限公司 2024-04-19 CN claimed
CN-117486823-A Nile blue derivative compound and preparation method and application thereof 西湖大学 2024-02-02 CN claimed
CN-116178689-A Liquid crystal polymer and preparation method and application thereof 深圳大学 2023-05-30 CN claimed
CN-114133387-B Fluorescent probe with viscosity sensing property and capable of targeting multiple organelles 郑州大学 2023-04-07 CN claimed
CN-112945912-B High-brightness large-Stokes-shift wash-free lipid-droplet fluorescent probe and synthetic method and application thereof 中国科学院大连化学物理研究所 2023-02-21 CN claimed
CN-115368292-A Benzoindole compound and synthetic method thereof 陕西科技大学 2022-11-22 CN claimed
CN-114907839-A Semi-aromatic polyimide-based high-brightness room temperature phosphorescent material and preparation method thereof 广州青苗新材料科技有限公司 2022-08-16 CN claimed
CN-114133387-A Fluorescent probe with viscosity sensing property and capable of targeting multiple organelles 郑州大学 2022-03-04 CN claimed
CN-112945912-A High-brightness large-Stokes-shift wash-free lipid-droplet fluorescent probe and synthetic method and application thereof 中国科学院大连化学物理研究所 2021-06-11 CN claimed
CN-111793042-A Method for synthesizing benzothiazole compound by taking aromatic amine without halogen as substrate 衡阳师范学院 2020-10-20 CN claimed
US-5635582-A Magnetic copolymer, a method of manufacture and applications thereof ALCATEL ALSTHOM COMPAGNIE GENERALE D'ELECTRICITE (FR) 1997-06-03 US claimed
JP-8151353-A None JP disclosed
JP-7278066-A None JP disclosed
US-12630566-B2 KRas G12D inhibitors Mirati Therapeutics, Inc. (US) 2026-05-19 US disclosed
US-20260098043-A1 POLYCYCLIC COMPOUND AND USE THEREOF HAINAN SIMCERE ZAIMING PHARMECEUTICAL CO LTD (CN) 2026-04-09 US disclosed
EP-0010842-A1 Polyurethane foam and method of preparation thereof UNIROYAL LTD. (CA) 1980-05-14 EP disclosed
US-4158542-A Acyldihydroxybenzene azo dyes for metallized polyolefins AMERICAN COLOR & CHEMICAL CORPORATION (US) 1979-06-19 US disclosed
US-4118383-A COLORFAST ON POLYESTER AND METALLIZED POLYPROPYLENE FIBERS AMERICAN COLOR & CHEMICAL CORPORATION (US) 1978-10-03 US disclosed
US-4089850-A FOR METAL MODIFIED POLYPROPYLENE AMERICAN COLOR & CHEMICAL CORPORATION (US) 1978-05-16 US disclosed
US-4066388-A DISAZO DYES DERIVED FROM 1-ACYL-2,4-DIHYDROXYBENZENES AND METALLIZED POLYOLEFIN DYED THEREWITH AMERICAN COLOR & CHEMICAL CORPORATION (US) 1978-01-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630566-B2 KRas G12D inhibitors KRAS, NRAS, HRAS ALDH1A1 1816/4885HPGD 968/4885CYP3A4 4044/4885
US-20260098043-A1 POLYCYCLIC COMPOUND AND USE THEREOF H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NR3C2, NR3C1 ALDH1A1 3149/4885HPGD 4659/4885CYP3A4 3552/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.