Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.62 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.62 |
| ▸ | MMP3 | P08254 | 1/20 | 0.62 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.62 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504777 | 0.88 | ADAM17 (0.65) | ADAM17ADAM10MMP3ADAM9MMP2 | |
| SCHEMBL1503648 | 0.87 | ADAM17 (0.59) | ADAM17ADAM10MMP3ADAM9MMP2 | |
| SCHEMBL1504674 | 0.84 | ADAM17 (0.61) | ADAM17ADAM10MMP3ADAM9ALDH1A1 | |
| SCHEMBL1504776 | 0.84 | ADAM17 (0.63) | ADAM17ADAM10MMP3MMP1 | |
| SCHEMBL10275858 | 0.82 | ADAM17 (0.83) | ADAM17ADAM10MMP3ADAM9MMP2 | |
| SCHEMBL1504584 | 0.82 | ADAM17 (0.83) | ADAM17ADAM10MMP3ADAM9MMP2 | |
| SCHEMBL10276287 | 0.82 | ADAM17 (0.83) | ADAM17ADAM10MMP3ADAM9MMP2 | |
| SCHEMBL1504682 | 0.81 | ADAM17 (0.41) | ADAM17ADAM10MMP3ADAM9ALDH1A1 | |
| SCHEMBL1504857 | 0.80 | ADAM17 (0.64) | ADAM17MMP13ALDH1A1 | |
| SCHEMBL1504780 | 0.77 | ADAM17 (0.81) | ADAM17ADAM10MMP3ADAM9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033009-A1 | N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |