Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 16/20 | 0.65 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 6/20 | 0.45 |
| ▸ | MMP1 | P03956 | 3/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504528 | 0.88 | ADAM17 (0.62) | ADAM17ADAM10MMP3ADAM9MMP13 | |
| SCHEMBL10276225 | 0.84 | ADAM17 (0.84) | ADAM17ADAM10MMP3ADAM9MMP13 | |
| SCHEMBL1504633 | 0.84 | ADAM17 (0.84) | ADAM17ADAM10MMP3ADAM9MMP13 | |
| SCHEMBL1503648 | 0.83 | ADAM17 (0.59) | ADAM17ADAM10MMP3ADAM9KDM4E | |
| SCHEMBL10275838 | 0.79 | ADAM17 (1.00) | ADAM17ADAM10MMP3ADAM9MMP1 | |
| SCHEMBL1504760 | 0.79 | ADAM17 (1.00) | ADAM17ADAM10MMP3ADAM9MMP1 | |
| SCHEMBL1504776 | 0.72 | ADAM17 (0.63) | ADAM17ADAM10MMP3MMP1 | |
| SCHEMBL1504674 | 0.72 | ADAM17 (0.61) | ADAM17ADAM10MMP3ADAM9 | |
| SCHEMBL21067889 | 0.70 | ADAM17 (0.73) | ADAM17KDM4EMMP13MMP2MMP8 | |
| SCHEMBL10275858 | 0.70 | ADAM17 (0.83) | ADAM17ADAM10MMP3ADAM9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033009-A1 | N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |