Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.55 |
| ▸ | HCN4 | Q9Y3Q4 | 7/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CCL2 | P13500 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.32 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.32 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537592 | 0.93 | BRD4 (0.57) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL15858417 | 0.83 | BRD4 (0.63) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL15858418 | 0.82 | BRD4 (0.64) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL18870119 | 0.82 | BRD4 (0.64) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL15044209 | 0.82 | BRD4 (0.32) | BRD4 | |
| SCHEMBL2450139 | 0.81 | BRD4 (0.63) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL2820668 | 0.81 | BRD4 (0.63) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL30285155 | 0.81 | BRD4 (0.63) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL10976351 | 0.80 | BRD4 (0.61) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL10986173 | 0.80 | BRD4 (0.58) | BRD4HCN4GAASMN1; SMN2CCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513410-B2 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2013-08-20 | — | — | US | disclosed |
| WO-2013093220-A1 | METHOD FOR SYNTHESISING IVABRADINE AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF | LES LABORATOIRES SERVIER (FR) | 2013-06-27 | — | — | WO | disclosed |
| EP-2607353-A1 | New method for synthesising ivabradine and its added salts with a pharmaceutically acceptable acid. | Les Laboratoires Servier (FR) | 2013-06-26 | — | — | EP | disclosed |
| US-20130158256-A1 | PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID | LES LABORATOIRES SERVIER (FR) | 2013-06-20 | — | — | US | disclosed |