Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.63 |
| ▸ | HCN4 | Q9Y3Q4 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CCL2 | P13500 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15858418 | 0.88 | BRD4 (0.64) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL18870119 | 0.88 | BRD4 (0.64) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL30285155 | 0.87 | BRD4 (0.63) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL2450139 | 0.87 | BRD4 (0.63) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL15858417 | 0.87 | BRD4 (0.63) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL10976351 | 0.86 | BRD4 (0.61) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL20254176 | 0.85 | BRD4 (0.68) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL334046 | 0.85 | BRD4 (0.60) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL10978343 | 0.84 | BRD4 (0.66) | BRD4HCN4GAASMN1; SMN2CCL2 | |
| SCHEMBL22738847 | 0.84 | BRD4 (0.66) | BRD4HCN4GAASMN1; SMN2CCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014020534-A1 | IVABRADINE HYDROCHLORIDE AND THE PROCESSES FOR PREPARATION THEREOF | BIOCON LIMITED (IN) | 2014-02-06 | — | — | WO | claimed |
| US-8212026-B2 | Process for the preparation of ivabradine hydrochloride and polymorph thereof | IND-SWIFT LABORATORIES LIMITED (US) | 2012-07-03 | — | — | US | claimed |
| US-20100179316-A1 | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF | IND-SWIFT LABORATORIES LIMITED (IN) | 2010-07-15 | — | — | US | claimed |
| EP-2162438-A2 | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF | Ind-Swift Laboratories Limited (IN) | 2010-03-17 | — | — | EP | claimed |
| WO-2008146308-A9 | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF | IND SWIFT LAB LTD (IN) | 2009-01-15 | — | — | WO | claimed |
| WO-2008146308-A2 | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF | IND-SWIFT LABORATORIES LIMITED (IN) | 2008-12-04 | — | — | WO | claimed |
| EP-3303297-B1 | NEW METHOD FOR THE PREPARATION OF HIGHLY PURE IVABRADINE BASE AND SALTS THEREOF | URQUIMA SA (ES) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019202611-A1 | AN IMPROVED PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | METROCHEM API PVT (IN) | 2019-10-24 | — | — | WO | disclosed |
| WO-2019202611-A1 | AN IMPROVED PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | METROCHEM API PVT (IN) | 2019-10-24 | — | — | WO | disclosed |
| US-10221141-B2 | Method for the preparation of highly pure ivabradine base and salts thereof | URQUIMA, S.A. (ES) | 2019-03-05 | — | — | US | disclosed |
| US-20180162820-A1 | NEW METHOD FOR THE PREPARATION OF HIGHLY PURE IVABRADINE BASE AND SALTS THEREOF | URQUIMA, S.A (ES) | 2018-06-14 | — | — | US | disclosed |
| US-20180162820-A1 | NEW METHOD FOR THE PREPARATION OF HIGHLY PURE IVABRADINE BASE AND SALTS THEREOF | URQUIMA, S.A (ES) | 2018-06-14 | — | — | US | disclosed |
| EP-2566850-B1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF IVABRADINE HYDROBROMIDE SALT | RICHTER GEDEON NYRT (HU) | 2018-04-11 | — | — | EP | disclosed |
| WO-2008146308-A9 | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF | IND SWIFT LAB LTD (IN) | 2009-01-15 | — | — | WO | disclosed |
| WO-2008146308-A9 | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF | IND SWIFT LAB LTD (IN) | 2009-01-15 | — | — | WO | disclosed |
| WO-2008146308-A2 | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF | IND-SWIFT LABORATORIES LIMITED (IN) | 2008-12-04 | — | — | WO | disclosed |
| WO-2008146308-A2 | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF | IND-SWIFT LABORATORIES LIMITED (IN) | 2008-12-04 | — | — | WO | disclosed |
| US-20070135411-A1 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2007-06-14 | — | — | US | disclosed |
| US-7176197-B2 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2007-02-13 | — | — | US | disclosed |
| US-5296482-A | (Benzocycloalkyl) alkylamines | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135411-A1 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | SCN5A, NISCH, CYP4F2 | BRD4 4110/4885HCN4 9/4885GAA 642/4885 |
| US-20100179316-A1 | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF | ADH1C, ADH1A, CYP4F2 | BRD4 4072/4885HCN4 28/4885GAA 1874/4885 |
| US-20180162820-A1 | NEW METHOD FOR THE PREPARATION OF HIGHLY PURE IVABRADINE BASE AND SALTS THEREOF | KCNH2, NISCH, KCNH3 | BRD4 403/4885HCN4 6/4885GAA 2381/4885 |
| US-10221141-B2 | Method for the preparation of highly pure ivabradine base and salts thereof | NISCH, KCNH2, KCNH3 | BRD4 573/4885HCN4 8/4885GAA 2111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.