Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Loperamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 10/20 | 1.00 |
| ▸ | DRD4 | P21917 | 5/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 3/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 2/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | HTR2B | P41595 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | FPR1 | P21462 | 1/20 | 1.00 |
| ▸ | C5AR1 | P21730 | 1/20 | 1.00 |
| ▸ | FPR2 | P25090 | 1/20 | 1.00 |
| ▸ | HTR1D | P28221 | 1/20 | 1.00 |
| ▸ | GPR183 | P32249 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Loperamide SCHEMBL21327979 | 1.00 | OPRM1 (1.00) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL9068543 | 1.00 | OPRM1 (1.00) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL8409268 | 1.00 | OPRM1 (1.00) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL2346867 | 0.99 | OPRM1 (0.98) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL28530 | 0.99 | OPRM1 (1.00) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL12387663 | 0.99 | OPRM1 (1.00) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL8409779 | 0.99 | OPRM1 (1.00) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL542589 | 0.97 | OPRM1 (0.96) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL3455728 | 0.96 | OPRM1 (0.92) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL5084617 | 0.96 | OPRM1 (0.94) | OPRM1DRD4ADRA2ASLC6A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 64780 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12629422-B2 | Agave syrup formulation or suspension for active pharmaceutical agents | GENEXA INC. (US) | 2026-05-19 | — | — | US | claimed |
| EP-4357981-B1 | HYBRID FERAM/OXRAM DATA STORAGE CIRCUIT | COMMISSARIAT ENERGIE ATOMIQUE (FR) | 2026-03-25 | — | — | EP | claimed |
| US-12585024-B2 | Ionospheric scintillation and total electron content monitoring system | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2026-03-24 | — | — | US | claimed |
| CN-223951557-U | Road compaction monitored control system | 黑龙江省一恒建设有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-12527745-B2 | Pharmaceutical dosage form for an emulsion of simethicone and loperamide | R.P. SCHERER TECHNOLOGIES, LLC (US) | 2026-01-20 | — | — | US | claimed |
| US-12394464-B2 | Hybrid FeRAM/OxRAM data storage circuit | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2025-08-19 | — | — | US | claimed |
| US-20250255781-A1 | PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-08-14 | — | — | US | claimed |
| US-12346333-B1 | Graphical user interface driven programming development environment | CODEBLOX, LLC | 2025-07-01 | — | — | US | claimed |
| CN-120123968-A | GNSSINS visual combined fire detection method, system, equipment and medium based on unmanned aerial vehicle | 浪潮智慧城市科技有限公司 | 2025-06-10 | — | — | CN | claimed |
| CN-120056143-A | Garlic sprout harvesting method based on Delta parallel mechanical arm harvesting robot | 山东农业大学 | 2025-05-30 | — | — | CN | claimed |
| WO-1980000843-A1 | DEPOLYMERISED CELLULOSIC MATERIAL WITH A LOW CRISTALLINE RATIO OBTAINED FROM CELLULOSE FIBRES AND METHOD OF PREPARATION | BATTELLE MEMORIAL INSTITUTE (US) | 1980-05-01 | — | — | WO | claimed |
| EP-0010463-A1 | Multiple use printing machine | Kis France Société dite: (FR) | 1980-04-30 | — | — | EP | claimed |
| EP-0010528-A2 | Device for separating and feeding V-shaped metallic strips | AMIA S.A.S. DI ALLIEVI ADOLFO & C. (IT) | 1980-04-30 | — | — | EP | claimed |
| EP-0010003-A1 | Apparatus for obtaining an electrical signal proportional to a number of movements and as such capable of detecting all movements or accelerations | SOCIETE D'ETUDES TECHNIQUES ET COMMERCIALES D'AUTOMATION S.E.T.E.C.A. (Société Anonyme) (FR) | 1980-04-16 | — | — | EP | claimed |
| EP-0008247-A1 | Electric window-raising device | DUCELLIER & Cie (FR) | 1980-02-20 | — | — | EP | claimed |
| EP-0004631-A2 | Packaging device and process therefor | "Conorelec" (BE) | 1979-10-17 | — | — | EP | claimed |
| EP-0004225-A1 | Process for the manufacture of a synthetic silicoaluminate and products obtained | RHONE-POULENC CHIMIE (FR) | 1979-09-19 | — | — | EP | claimed |
| EP-0001528-A1 | Supporting device for the hot blast duct of a blast furnace | UNION SIDERURGIQUE DU NORD ET DE L'EST DE LA FRANCE par abréviation "USINOR" (FR) | 1979-04-18 | — | — | EP | claimed |
| EP-0001373-A1 | Method of forming smooth and pinhole-free silicon carbide films on a silicon substrate | International Business Machines Corporation (US) | 1979-04-04 | — | — | EP | claimed |
| WO-1979000120-A1 | MACHINING PROCESS BY ELECTRO-EROSION AND SYSTEM FOR APPLYING SUCH PROCESS | LANGUEPIN C (FR) | 1979-03-22 | — | — | WO | claimed |