Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Loperamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 10/20 | 1.00 |
| ▸ | DRD4 | P21917 | 5/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 3/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 2/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | HTR2B | P41595 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | FPR1 | P21462 | 1/20 | 1.00 |
| ▸ | C5AR1 | P21730 | 1/20 | 1.00 |
| ▸ | FPR2 | P25090 | 1/20 | 1.00 |
| ▸ | HTR1D | P28221 | 1/20 | 1.00 |
| ▸ | GPR183 | P32249 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Loperamide SCHEMBL15048 | 1.00 | OPRM1 (1.00) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL21327979 | 1.00 | OPRM1 (1.00) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL9068543 | 1.00 | OPRM1 (1.00) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL2346867 | 0.99 | OPRM1 (0.98) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL28530 | 0.99 | OPRM1 (1.00) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL12387663 | 0.99 | OPRM1 (1.00) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL8409779 | 0.99 | OPRM1 (1.00) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL542589 | 0.97 | OPRM1 (0.96) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL3455728 | 0.96 | OPRM1 (0.92) | OPRM1DRD4ADRA2ASLC6A4MEN1 | |
| Loperamide SCHEMBL5084617 | 0.96 | OPRM1 (0.94) | OPRM1DRD4ADRA2ASLC6A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5980944-A | A SOLID ORAL DOSAGE FORM FOR THE TREATMENT OF GASTROINTESTINAL DISTRESS COMPRISING SIMETHICONE AND COATED ACTIVE GRANULES WITH A NONENTERIC POLYMER COATINGS IMPERMEABLE TO SIMETHICONE | MCNEIL-PPC, INC. (US) | 1999-11-09 | — | — | US | disclosed |
| US-5716641-A | SOLID DOSAGE FORM HAVING DIPHENOXYLATE OR LOPERAMIDE(OR DERIVATIVES) IN FIRST PART AND SIMETHICONE IN SECOND PART WHICH IS SEPARATED BY AN IMPERMEABLE POLYMERIC BARRIER, FOR ENHANCING THE DISSOLUTION PROFILE OF THE DRUG | MCNEIL-PPC, INC. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5679376-A | DIPHENOXYLATE, LOPERAMIDE, AND DERIVATIVES AS TREATMENT FOR GASTROINTESTINAL DISORDERS | MCNEIL-PPC, INC. (US) | 1997-10-21 | — | — | US | disclosed |
| US-5599577-A | DRUG DELIVERY; GASTROINTESTINAL DISORDERS | MCNEIL-PPC, INC. (US) | 1997-02-04 | — | — | US | disclosed |