Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4206169 | 0.85 | HRH3 (0.40) | MAPTTP53LMNAALDH1A1ATM | |
| SCHEMBL1546199 | 0.80 | KMT2A (0.58) | MAPTTP53LMNAALDH1A1ATM | |
| SCHEMBL4201243 | 0.79 | HRH3 (0.41) | MAPTTP53LMNAALDH1A1ATM | |
| SCHEMBL4201240 | 0.79 | HRH3 (0.41) | MAPTTP53LMNAALDH1A1ATM | |
| SCHEMBL1546795 | 0.78 | SMN1; SMN2 (0.49) | MAPTTP53LMNAALDH1A1ATM | |
| SCHEMBL1546424 | 0.76 | DRD2 (0.56) | MAPTTP53LMNAALDH1A1ATM | |
| SCHEMBL1546298 | 0.75 | ALDH1A1 (0.45) | MAPTTP53LMNAALDH1A1ATM | |
| SCHEMBL1546294 | 0.75 | ALDH1A1 (0.56) | MAPTTP53LMNAALDH1A1ATM | |
| SCHEMBL1546292 | 0.75 | ALDH1A1 (0.56) | MAPTTP53LMNAALDH1A1ATM | |
| SCHEMBL1546299 | 0.74 | SMN1; SMN2 (0.53) | MAPTTP53LMNAALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470810-B2 | Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor | ABBOTT GMBH & CO. KG (DE) | 2013-06-25 | — | — | US | claimed |