Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | ATR | Q13535 | 2/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | NPM1 | P06748 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.32 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15048648 | 0.91 | ALK (0.46) | INSRJAK2ALKNPM1RPS6KA3 | |
| SCHEMBL521023 | 0.81 | INSR (0.69) | INSRJAK2ALKNPM1KCNH2 | |
| SCHEMBL3477297 | 0.80 | JAK2 (0.46) | INSRJAK2ATRATRIPALK | |
| SCHEMBL3478153 | 0.79 | JAK2 (0.46) | INSRJAK2ATRATRIPALK | |
| SCHEMBL15048633 | 0.79 | INSR (0.45) | INSRJAK2ALKNPM1MAPK10 | |
| SCHEMBL15048651 | 0.74 | ALK (0.50) | INSRJAK2ALKNPM1 | |
| SCHEMBL3478509 | 0.73 | JAK2 (0.46) | INSRJAK2ATRATRIPALK | |
| SCHEMBL3478601 | 0.73 | JAK2 (0.48) | INSRJAK2ALKPIK3CANPM1 | |
| SCHEMBL520948 | 0.72 | ALK (0.71) | INSRJAK2ALKNPM1 | |
| SCHEMBL3476710 | 0.71 | ALK (0.48) | INSRJAK2ALKNPM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |