Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 10/20 | 0.45 |
| ▸ | JAK2 | O60674 | 6/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.39 |
| ▸ | NPM1 | P06748 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15048644 | 0.92 | ALK (0.46) | INSRJAK2ALKNPM1CYP3A4 | |
| SCHEMBL521763 | 0.80 | INSR (0.69) | INSRJAK2ALKNPM1CYP3A4 | |
| SCHEMBL15048631 | 0.79 | INSR (0.44) | INSRJAK2ALKNPM1MAPK10 | |
| SCHEMBL3478153 | 0.78 | JAK2 (0.46) | INSRJAK2ALKNPM1CYP3A4 | |
| SCHEMBL3477297 | 0.77 | JAK2 (0.46) | INSRJAK2ALKNPM1CYP3A4 | |
| SCHEMBL3478509 | 0.76 | JAK2 (0.46) | INSRJAK2ALKNPM1CYP3A4 | |
| SCHEMBL3478601 | 0.76 | JAK2 (0.48) | INSRJAK2ALKNPM1CYP3A4 | |
| SCHEMBL521250 | 0.72 | ALK (0.71) | INSRJAK2ALKNPM1CYP3A4 | |
| SCHEMBL15048648 | 0.71 | ALK (0.46) | INSRJAK2ALKNPM1CYP3A4 | |
| SCHEMBL15048651 | 0.71 | ALK (0.50) | INSRJAK2ALKNPM1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |