Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.57 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.57 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.57 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.57 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.57 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.57 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.56 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.56 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.56 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.56 |
| ▸ | CASR | P41180 | 9/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.57 |
| ▸ | MLNR | O43193 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1504865 | 1.00 | CASR (0.57) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL1331216 | 0.99 | CASR (0.58) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL1491268 | 0.99 | CASR (0.58) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL1331214 | 0.99 | CASR (0.58) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL1491266 | 0.99 | CASR (0.58) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL2873634 | 0.98 | CASR (0.59) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL2873629 | 0.98 | CASR (0.59) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL1505053 | 0.98 | CASR (0.59) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL1505054 | 0.98 | CASR (0.59) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Phosphoric Acid SCHEMBL15556906 | 0.93 | CASR (0.53) | CASRADRA2CSLC6A2HTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759586-B2 | Processes for the preparation of cinacalcet | RANBAXY LABORATORIES LIMITED (IN) | 2014-06-24 | — | — | US | disclosed |
| US-20120309842-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | RANBAXY LABORATORIES LIMITED (IN) | 2012-12-06 | — | — | US | disclosed |
| EP-2477959-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | Ranbaxy Laboratories Limited (IN) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011033473-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | RANBAXY LABORATORIES LIMITED (IN) | 2011-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309842-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | CA4, SI, CA9 | ADRA2C 1904/4885SLC6A2 968/4885SLC6A4 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.