Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 9/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | MLNR | O43193 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.58 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.58 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | MC3R | P41968 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1491266 | 1.00 | CASR (0.58) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL1491268 | 1.00 | CASR (0.58) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| SCHEMBL1331216 | 1.00 | CASR (0.58) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Bromide SCHEMBL1504865 | 0.99 | CASR (0.57) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL1505053 | 0.99 | CASR (0.59) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL2873634 | 0.99 | CASR (0.59) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL1505054 | 0.99 | CASR (0.59) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL2873629 | 0.99 | CASR (0.59) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Bromide SCHEMBL1504864 | 0.99 | CASR (0.57) | CASRADRA2CSLC6A2HTR2CSLC6A4 | |
| Phosphoric Acid SCHEMBL15556906 | 0.94 | CASR (0.53) | CASRADRA2CSLC6A2HTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309842-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | RANBAXY LABORATORIES LIMITED (IN) | 2012-12-06 | — | — | US | claimed |
| EP-2477959-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | Ranbaxy Laboratories Limited (IN) | 2012-07-25 | — | — | EP | claimed |
| WO-2011033473-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | RANBAXY LABORATORIES LIMITED (IN) | 2011-03-24 | — | — | WO | claimed |
| US-20180155270-A1 | PROCESS FOR PREPARATION OF CINACALCET INTERMEDIATE AND CINACALCET HYDROCHLORIDE | LUPIN LIMITED (IN) | 2018-06-07 | — | — | US | disclosed |
| US-9522869-B2 | Process for preparing Cinacalcet hydrochloride | ZACH SYSTEM S.P.A. (IT) | 2016-12-20 | — | — | US | disclosed |
| US-9522869-B2 | Process for preparing Cinacalcet hydrochloride | ZACH SYSTEM S.P.A. (IT) | 2016-12-20 | — | — | US | disclosed |
| WO-2016193882-A1 | PROCESS FOR PREPARATION OF CINACALCET INTERMEDIATE AND CINACALCET HYDROCHLORIDE | LUPIN LIMITED (IN) | 2016-12-08 | — | — | WO | disclosed |
| EP-2170805-B1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | AMGEN INC (US) | 2016-03-16 | — | — | EP | disclosed |
| EP-2170805-B1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | AMGEN INC (US) | 2016-03-16 | — | — | EP | disclosed |
| US-20150152040-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | AMNEAL PHARMACEUTICALS LLC (US) | 2015-06-04 | — | — | US | disclosed |
| US-20150152040-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | AMNEAL PHARMACEUTICALS LLC (US) | 2015-06-04 | — | — | US | disclosed |
| US-20090137837-A1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | AMGEN INC. | 2009-05-28 | — | — | US | disclosed |
| WO-2009002427-A2 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | AMGEN INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009002427-A2 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | AMGEN INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| US-7393967-B2 | Process for the preparation of cinacalcet base | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-07-01 | — | — | US | disclosed |
| US-7393967-B2 | Process for the preparation of cinacalcet base | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-07-01 | — | — | US | disclosed |
| WO-2008019690-A1 | SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES | LEO PHARMA A/S (DK) | 2008-02-21 | — | — | WO | disclosed |
| US-20070260091-A1 | Process for the preparation of cinacalcet base | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-11-08 | — | — | US | disclosed |
| US-20070260091-A1 | Process for the preparation of cinacalcet base | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-11-08 | — | — | US | disclosed |
| WO-2007127449-A1 | PROCESS FOR THE PREPARATION OF CINACALCET BASE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309842-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | CA4, SI, CA9 | CASR 147/4885ADRA2C 1904/4885SLC6A2 968/4885 |
| US-20180155270-A1 | PROCESS FOR PREPARATION OF CINACALCET INTERMEDIATE AND CINACALCET HYDROCHLORIDE | SI, ACSL4, C9 | CASR 574/4885ADRA2C 1293/4885SLC6A2 1675/4885 |
| US-20070260091-A1 | Process for the preparation of cinacalcet base | KRAS, CA9, SI | CASR 339/4885ADRA2C 1918/4885SLC6A2 763/4885 |
| US-20090137837-A1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | ACE, SI, REN | CASR 71/4885ADRA2C 1439/4885SLC6A2 330/4885 |
| US-20150152040-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | CMA1, SI, ALDH1A1 | CASR 1464/4885ADRA2C 267/4885SLC6A2 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.