Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.32 |
| ▸ | F11 | P03951 | 2/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963450 | 0.77 | F11 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL960931 | 0.68 | F11 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL962344 | 0.65 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL961832 | 0.65 | UGT1A1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Iodide SCHEMBL960829 | 0.64 | UGT1A1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL155131 | 0.61 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL155570 | 0.60 | PSEN1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15062288 | 0.59 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12918119 | 0.59 | NOS3 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL511504 | 0.59 | NR4A1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379553-B1 | BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL MYERS SQUIBB CO (US) | 2013-06-26 | — | — | EP | disclosed |