Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | PANK3 | Q9H999 | 6/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857665 | 0.81 | USP30 (0.60) | DPP4USP30RETPANK3CHRM4 | |
| SCHEMBL16128015 | 0.80 | ALDH1A1 (0.52) | USP30 | |
| SCHEMBL3454291 | 0.72 | PANK3 (0.49) | DPP4USP30PANK3GPR119 | |
| SCHEMBL26292225 | 0.71 | PANK3 (0.59) | RETPANK3CHRM4GPR119 | |
| SCHEMBL21521672 | 0.70 | PANK3 (0.48) | RETPANK3 | |
| SCHEMBL31465015 | 0.70 | PANK3 (0.48) | RETPANK3 | |
| SCHEMBL3104516 | 0.70 | TACR3 (0.54) | DPP4CHRM4TACR3 | |
| SCHEMBL26290833 | 0.69 | TIPARP (0.56) | DPP4PANK3CHRM4GPR119 | |
| SCHEMBL12639817 | 0.68 | GPR119 (0.56) | DPP4PANK3JAK2JAK1JAK3 | |
| SCHEMBL3859652 | 0.68 | CHRM4 (0.54) | DPP4PANK3JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013096093-A1 | COMPOUNDS AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013096093-A1 | COMPOUNDS AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-06-27 | — | — | WO | disclosed |