Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.53 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.42 |
| ▸ | ACLY | P53396 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 3/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15056109 | 0.80 | ACLY (0.52) | RORCACLYSMN1; SMN2EGFRMEN1 | |
| SCHEMBL15055749 | 0.78 | RORC (0.49) | RORCPFKFB3SMN1; SMN2EGFRFABP4 | |
| SCHEMBL15055055 | 0.77 | RORC (0.46) | RORCPFKFB3ACLYSMN1; SMN2EGFR | |
| SCHEMBL15056187 | 0.73 | PFKFB3 (0.50) | PFKFB3ACLYSMN1; SMN2FABP4FABP5 | |
| SCHEMBL15055727 | 0.73 | PFKFB3 (0.50) | PFKFB3ACLYSMN1; SMN2FABP4FABP5 | |
| SCHEMBL15055884 | 0.72 | MCL1 (0.61) | ACLYSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL15055913 | 0.71 | SMN1; SMN2 (0.49) | RORCSMN1; SMN2EGFRMEN1USP2 | |
| SCHEMBL9997292 | 0.70 | SMN1; SMN2 (0.46) | RORCSMN1; SMN2EGFRMEN1USP2 | |
| SCHEMBL15056207 | 0.70 | PFKFB3 (0.58) | PFKFB3ACLYSMN1; SMN2EGFRMEN1 | |
| SCHEMBL15055741 | 0.70 | PFKFB3 (0.68) | PFKFB3ACLYSMN1; SMN2FABP4FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794009-A1 | BISARYLSULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION AND CANCER | Kancera AB (SE) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013093095-A1 | BISARYLSULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION AND CANCER | KANCERA AB (SE) | 2013-06-27 | — | — | WO | disclosed |