Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TACR2 | P21452 | 1/20 | 0.43 |
| ▸ | PNLIP | P16233 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30628472 | 0.85 | TTR (0.57) | HSD17B10TTRALDH1A1HPGDMAPT | |
| SCHEMBL21190855 | 0.84 | ALDH1A1 (0.49) | TTRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL24512660 | 0.83 | TTR (0.60) | HSD17B10TTRALDH1A1HPGDMAPT | |
| SCHEMBL203768 | 0.83 | TTR (0.64) | TTRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL25047358 | 0.81 | ALDH1A1 (0.49) | HSD17B10TTRALDH1A1HPGDMAPT | |
| SCHEMBL23120903 | 0.81 | HSD17B10 (0.47) | HSD17B10TTRALDH1A1HPGDMAPT | |
| SCHEMBL18304466 | 0.80 | MAPT (0.49) | TTRALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL16791716 | 0.80 | TTR (0.50) | HSD17B10TTRALDH1A1HPGDMAPT | |
| SCHEMBL2991888 | 0.80 | GAA (0.53) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL26936729 | 0.79 | TTR (0.72) | TTRALDH1A1HPGDMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019141131-A1 | BROMODOMAIN INHIBITOR COMPOUND AND USE THEREOF | 中国科学院上海药物研究所 | 2019-07-25 | — | — | WO | disclosed |
| WO-2013093688-A1 | SULFONAMIDE DERIVATIVES AND USE THEREOF AS VGSC INHIBITORS | PFIZER LIMITED (GB) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013093688-A1 | SULFONAMIDE DERIVATIVES AND USE THEREOF AS VGSC INHIBITORS | PFIZER LIMITED (GB) | 2013-06-27 | — | — | WO | disclosed |