SCHEMBL15055583

SCHEMBL15055583

C[Si](C)(C)C#Cc1ncc(F)cc1N

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19709312 0.81 PIK3CA (0.31)
SCHEMBL1150077 0.81 NOS3 (0.41)
SCHEMBL1748589 0.79 NOS3 (0.34)
SCHEMBL17883465 0.79 IDO1 (0.35)
SCHEMBL21148071 0.74
SCHEMBL12709590 0.73 CREBBP (0.36)
SCHEMBL1149971 0.73 MEN1 (0.35)
SCHEMBL30834616 0.73 PIK3CD (0.51)
SCHEMBL18109302 0.73 PIK3CD (0.51)
SCHEMBL24869418 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250388571-A1 AMP-ACTIVATED PROTEIN KINASE MODULATOR COMPOUNDS AND USES THEREOF BIOLEXIS THERAPEUTICS INC (US) 2025-12-25 US disclosed
US-20250206753-A1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE ABBVIE INC. 2025-06-26 US disclosed
US-20240025914-A1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE AKARNA THERAPEUTICS LTD (GB) 2024-01-25 US disclosed
US-20240025914-A1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE AKARNA THERAPEUTICS LTD (GB) 2024-01-25 US disclosed
US-20240025914-A1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE AKARNA THERAPEUTICS LTD (GB) 2024-01-25 US disclosed
US-20210139490-A1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE AKARNA THERAPEUTICS LTD (GB) 2021-05-13 US disclosed
US-20210139490-A1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE AKARNA THERAPEUTICS LTD (GB) 2021-05-13 US disclosed
EP-3237419-B1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE AKARNA THERAPEUTICS LTD (GB) 2021-02-17 EP disclosed
EP-3237419-B1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE AKARNA THERAPEUTICS LTD (GB) 2021-02-17 EP disclosed
US-10793577-B2 Fused bicyclic compounds for the treatment of disease AKARNA THERAPEUTICS, LTD. (GB) 2020-10-06 US disclosed
US-10167294-B2 Fused bicyclic compounds for the treatment of disease AKARNA THERAPEUTICS, LTD. (GB) 2019-01-01 US disclosed
US-10167294-B2 Fused bicyclic compounds for the treatment of disease AKARNA THERAPEUTICS, LTD. (GB) 2019-01-01 US disclosed
US-20170355704-A1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE ABBVIE INC. 2017-12-14 US disclosed
US-20170355704-A1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE ABBVIE INC. 2017-12-14 US disclosed
US-20170355704-A1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE ABBVIE INC. 2017-12-14 US disclosed
WO-2016103037-A1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE AKARNA THERAPEUTICS, LTD. (GB) 2016-06-30 WO disclosed
EP-2794605-A1 2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2014-10-29 EP disclosed
US-8815877-B2 Serine/threonine kinase inhibitors GENENTECH, INC. (US) 2014-08-26 US disclosed
US-20130178486-A1 SERINE/THREONINE KINASE INHIBITORS GENENTECH, INC. (US) 2013-07-11 US disclosed
WO-2013092940-A1 2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2013-06-27 WO disclosed