⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2528783 | 1.00 | — | — | |
| SCHEMBL18194652 | 0.85 | CA2 (0.32) | — | |
| SCHEMBL1691302 | 0.83 | — | — | |
| SCHEMBL1690712 | 0.83 | — | — | |
| SCHEMBL1690710 | 0.83 | — | — | |
| SCHEMBL16614403 | 0.82 | — | — | |
| SCHEMBL8993618 | 0.82 | CA2 (0.38) | — | |
| SCHEMBL16614349 | 0.82 | — | — | |
| SCHEMBL18194646 | 0.82 | — | — | |
| SCHEMBL16928564 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791144-B2 | Substituted N-phenyl-1-(4-Pyridinyl)-1H-pyrazol-3-amines | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-29 | — | — | US | disclosed |
| US-8791144-B2 | Substituted N-phenyl-1-(4-Pyridinyl)-1H-pyrazol-3-amines | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-29 | — | — | US | disclosed |
| EP-2491024-B1 | SUBSTITUTED N-PHENYL-1-(4-PYRIDINYL)-1H-PYRAZOL-3-AMINES | JANSSEN PHARMACEUTICA NV (BE) | 2013-11-20 | — | — | EP | disclosed |
| EP-2491024-A1 | SUBSTITUTED N-PHENYL-1-(4-PYRIDINYL)-1H-PYRAZOL-3-AMINES | Janssen Pharmaceutica N.V. (BE) | 2012-08-29 | — | — | EP | disclosed |
| US-20120172354-A1 | Substituted N-Phenyl-1-(4-Pyridinyl)-1H-Pyrazol-3-Amines | JANSSEN PHARMACEUTICA NV (BE) | 2012-07-05 | — | — | US | disclosed |
| US-20120172354-A1 | Substituted N-Phenyl-1-(4-Pyridinyl)-1H-Pyrazol-3-Amines | JANSSEN PHARMACEUTICA NV (BE) | 2012-07-05 | — | — | US | disclosed |
| US-8039465-B2 | Cytoskeletal active compounds, composition and use | INSPIRE PHARMACEUTICALS, INC. (US) | 2011-10-18 | — | — | US | disclosed |
| WO-2011033018-A1 | SUBSTITUTED N-PHENYL-1-(4-PYRIDINYL)-1H-PYRAZOL-3-AMINES | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-24 | — | — | WO | disclosed |
| US-20100130572-A1 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | LAMPE JOHN W | 2010-05-27 | — | — | US | disclosed |
| US-7666861-B2 | Cytoskeletal active compounds, composition and use | INSPIRE PHARMACEUTICALS, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| US-20080076735-A1 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | CHATTEM INC. | 2008-03-27 | — | — | US | disclosed |
| US-7320974-B2 | Cytoskeletal active compounds, compositions and use | INSPIRE PHARMACEUTICALS, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1866316-A2 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | Inspire Pharmaceuticals, Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006104897-A2 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | INSPIRE PHARMACEUTICALS, INC. (US) | 2006-10-05 | — | — | WO | disclosed |
| US-20060217427-A1 | Cytoskeletal active compounds, compositions and use | INSPIRE PHARMACEUTICALS, INC. | 2006-09-28 | — | — | US | disclosed |