Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17501149 | 0.82 | LPL (0.37) | PDGFRBKDRAAK1ALPLCA1 | |
| SCHEMBL15056826 | 0.80 | ALPL (0.37) | PDGFRBKDRAAK1ALPLCA1 | |
| SCHEMBL15056858 | 0.79 | ALPL (0.36) | PDGFRBKDRAAK1ALPLCA1 | |
| SCHEMBL17609622 | 0.79 | AAK1 (0.39) | PDGFRBKDRAAK1ALPLDGAT1 | |
| SCHEMBL15056872 | 0.78 | AAK1 (0.47) | PDGFRBKDRAAK1ALPLCA1 | |
| SCHEMBL15079342 | 0.78 | GSK3A (0.36) | PDGFRBKDRAAK1ALPLCA1 | |
| SCHEMBL23275245 | 0.77 | AAK1 (0.40) | PDGFRBKDRAAK1DGAT1GSK3A | |
| SCHEMBL30805509 | 0.77 | PDGFRB (0.44) | PDGFRBKDRAAK1DGAT1GSK3A | |
| SCHEMBL30507065 | 0.77 | PDGFRB (0.40) | PDGFRBKDRAAK1DGAT1GSK3A | |
| SCHEMBL182702 | 0.77 | PDGFRB (0.44) | PDGFRBKDRAAK1DGAT1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148377-A1 | Quinoline Derivatives | NOVARTIS AG (CH) | 2015-05-28 | — | — | US | disclosed |
| US-20150148377-A1 | Quinoline Derivatives | NOVARTIS AG (CH) | 2015-05-28 | — | — | US | disclosed |
| US-20150148377-A1 | Quinoline Derivatives | NOVARTIS AG (CH) | 2015-05-28 | — | — | US | disclosed |
| EP-2794594-A1 | QUINOLINE DERIVATIVES | Novartis AG (CH) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013093850-A1 | QUINOLINE DERIVATIVES | NOVARTIS AG (CH) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013093850-A1 | QUINOLINE DERIVATIVES | NOVARTIS AG (CH) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148377-A1 | Quinoline Derivatives | RECQL, NQO2, PIK3R3 | PDGFRB 2742/4885KDR 3521/4885AAK1 2639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.