Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 6/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15058621 | 1.00 | GPR119 (0.48) | GPR119CHRM2CHRM1CHRM3SCD | |
| SCHEMBL15058620 | 1.00 | GPR119 (0.48) | GPR119CHRM2CHRM1CHRM3SCD | |
| SCHEMBL16286483 | 0.86 | CHRM2 (0.44) | GPR119CHRM2CHRM1CHRM3SCD | |
| SCHEMBL16286481 | 0.86 | CHRM2 (0.44) | GPR119CHRM2CHRM1CHRM3SCD | |
| SCHEMBL15060436 | 0.86 | GPR119 (0.48) | GPR119CHRM2CHRM1CHRM3PREP | |
| SCHEMBL16286601 | 0.86 | GPR119 (0.48) | GPR119CHRM2CHRM1CHRM3PREP | |
| SCHEMBL16286600 | 0.86 | GPR119 (0.48) | GPR119CHRM2CHRM1CHRM3PREP | |
| SCHEMBL16286504 | 0.83 | SCD (0.47) | SCDSCD5 | |
| SCHEMBL16286503 | 0.83 | SCD (0.47) | SCDSCD5 | |
| SCHEMBL16023863 | 0.83 | CHRM2 (0.45) | GPR119CHRM2CHRM1CHRM3SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794608-B1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2016-09-14 | — | — | EP | disclosed |
| US-9403835-B2 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators | ARES TRADING S.A. (CH) | 2016-08-02 | — | — | US | disclosed |
| EP-2794608-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | Merck Patent GmbH (DE) | 2014-10-29 | — | — | EP | disclosed |
| EP-2674434-A1 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators | ARES TRADING S.A. (CH) | 2013-12-18 | — | — | EP | disclosed |
| WO-2013091773-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2013-06-27 | — | — | WO | disclosed |