Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16286600 | 1.00 | GPR119 (0.48) | GPR119CHRM2CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL16286601 | 1.00 | GPR119 (0.48) | GPR119CHRM2CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL12345388 | 0.86 | GPR119 (0.53) | GPR119CHRM2CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL12094679 | 0.86 | GPR119 (0.53) | GPR119CHRM2CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL17947875 | 0.86 | GPR119 (0.53) | GPR119CHRM2CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL16286592 | 0.86 | CHRM2 (0.43) | GPR119CHRM2CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL16286593 | 0.86 | CHRM2 (0.43) | GPR119CHRM2CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL17752644 | 0.86 | CHRM2 (0.43) | GPR119CHRM2CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL15058621 | 0.86 | GPR119 (0.48) | GPR119CHRM2CHRM1CHRM3PREP | |
| SCHEMBL15058619 | 0.86 | GPR119 (0.48) | GPR119CHRM2CHRM1CHRM3PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794608-B1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2016-09-14 | — | — | EP | disclosed |
| EP-2794608-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | Merck Patent GmbH (DE) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013091773-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013091773-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2013-06-27 | — | — | WO | disclosed |