SCHEMBL15058720

SCHEMBL15058720

COC(=O)c1ccccc1CC1CCN(C)CC1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SCN1A P35498 5/20 0.53
SCN2A Q99250 5/20 0.53
SCN3A Q9NY46 5/20 0.53
KDM4E B2RXH2 4/20 0.49
MAPK1 P28482 1/20 0.49
ALDH1A1 P00352 4/20 0.48
LMNA P02545 1/20 0.48
HPGD P15428 1/20 0.46
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
MAPK14 Q16539 1/20 0.44
MAPT P10636 1/20 0.43
SIRT1 Q96EB6 1/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
USP2 O75604 1/20 0.43
PKM P14618 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27984073 0.86 CYP2C9 (0.51) KDM4EMAPK1ALDH1A1LMNACYP2C9
SCHEMBL15058447 0.84 SCN1A (0.50) SCN1ASCN2ASCN3AALDH1A1CYP2C9
SCHEMBL30002493 0.83 PARP2 (0.46) SCN1ASCN2ASCN3ACYP2C9CYP2C19
SCHEMBL15058311 0.81 KDM4E (0.56) KDM4EALDH1A1LMNAMAPTPKM
SCHEMBL10514159 0.77 ALDH1A1 (0.48) SCN1ASCN2ASCN3AALDH1A1CYP2C9
SCHEMBL6585398 0.77 HDAC3 (0.56) SCN1ASCN2ASCN3AKDM4EALDH1A1
SCHEMBL24590532 0.76 CCR3 (0.42) SCN1ASCN2ASCN3AALDH1A1HPGD
SCHEMBL29818193 0.76 BRD4 (0.44) SCN1ASCN2ASCN3ACYP2C9CYP2C19
SCHEMBL19064421 0.76 KDM4E (0.47) KDM4EMAPK1ALDH1A1LMNACYP2C9
SCHEMBL14289424 0.75 RBP4 (0.51) SCN1ASCN2ASCN3AKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2794608-B1 TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS MERCK PATENT GMBH (DE) 2016-09-14 EP disclosed
US-9403835-B2 Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators ARES TRADING S.A. (CH) 2016-08-02 US disclosed
EP-2794608-A1 TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS Merck Patent GmbH (DE) 2014-10-29 EP disclosed
EP-2674434-A1 Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators ARES TRADING S.A. (CH) 2013-12-18 EP disclosed
WO-2013091773-A1 TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS MERCK PATENT GMBH (DE) 2013-06-27 WO disclosed