⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL97737 | 1.00 | — | — | |
| SCHEMBL322745 | 1.00 | — | — | |
| SCHEMBL13286127 | 0.89 | TSHR (0.39) | — | |
| SCHEMBL14337002 | 0.89 | TSHR (0.39) | — | |
| SCHEMBL28243 | 0.87 | TSHR (0.50) | — | |
| SCHEMBL15892735 | 0.85 | KDM4E (0.41) | — | |
| SCHEMBL11607945 | 0.84 | MGAM (0.41) | — | |
| SCHEMBL21551859 | 0.83 | L3MBTL1 (0.49) | — | |
| SCHEMBL21551893 | 0.83 | L3MBTL1 (0.49) | — | |
| SCHEMBL21551920 | 0.83 | L3MBTL1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630424-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | Third Harmonic Bio, Inc. (US) | 2025-10-15 | — | — | EP | disclosed |
| US-20240254119-A1 | COMPOUNDS AND COMPOSITIONS AS c-Kit KINASE INHIBITORS | Calixis Inc. | 2024-08-01 | — | — | US | disclosed |
| WO-2024124002-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |
| CN-102947310-B | Fused pyridine compounds as dual modulators of the 5-HT2A and D3 receptors | HOFFMAN-LA ROCHE LTD. (CH) | 2015-11-25 | — | — | CN | disclosed |
| US-8921397-B2 | Benzofurane-piperidine compounds | HOFFMANN-LA ROCHE INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8877778-B2 | Benzofurane compounds | HOFFMANN-LA ROCHE INC. (US) | 2014-11-04 | — | — | US | disclosed |
| CN-102574832-B | Substituted N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amines | JANSSEN PHARMACEUTICA NV | 2014-09-24 | — | — | CN | disclosed |
| US-8791144-B2 | Substituted N-phenyl-1-(4-Pyridinyl)-1H-pyrazol-3-amines | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-29 | — | — | US | disclosed |
| EP-2704707-A1 | NOVEL BENZOFURANE-PIPERIDINE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2014-03-12 | — | — | EP | disclosed |
| CN-103501780-A | Novel benzofurane-piperidine compounds | HOFFMANN LA ROCHE | 2014-01-08 | — | — | CN | disclosed |
| US-5258553-A | Chiral tridentate bis(phospholane) ligands | E. I. DUPONT DE NEMOURS AND COMPANY (US) | 1993-11-02 | — | — | US | disclosed |
| US-5250731-A | Asymmetric hydrogenation of N-acylhydrazones to N-acylhydrazines in presence of chiral phospholane complex | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-10-05 | — | — | US | disclosed |
| WO-1993019040-A1 | PREPARATION OF OPTICALLY ACTIVE HYDRAZINES AND AMINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-09-30 | — | — | WO | disclosed |
| US-5221755-A | Optically active ether lactone, optically active polymer thereof, and process for producing the polymer | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1993-06-22 | — | — | US | disclosed |
| US-5202493-A | CHIRAL TRIDENTATE BIS(PHOSPHOLANE) LIGANDS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-04-13 | — | — | US | disclosed |
| WO-1993001199-A1 | CHIRAL PHOSPHOLANES VIA CHIRAL 1,4-DIOL CYCLIC SULFATES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-01-21 | — | — | WO | disclosed |
| US-5171892-A | Chiral phospholanes via chiral 1,4-diol cyclic sulfates | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-12-15 | — | — | US | disclosed |
| WO-1992019630-A1 | CHIRAL TRIDENTATE BIS(PHOSPHOLANE) LIGANDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-11-12 | — | — | WO | disclosed |
| US-5128252-A | Resolution of optically active esters, transesterification, lipase | CHISSO CORPORATION (JP) | 1992-07-07 | — | — | US | disclosed |
| EP-0384189-A2 | Optically active compound and a process for the production thereof | CHISSO CORPORATION (JP) | 1990-08-29 | — | — | EP | disclosed |