Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 5/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1505822 | 0.81 | KDM4E (0.42) | GPR119HTTKMT2AKIT | |
| SCHEMBL1505784 | 0.79 | GPR119 (0.46) | GPR119KITMMP13KCNH2 | |
| SCHEMBL1505743 | 0.73 | GPR119 (0.70) | GPR119MMP13KCNH2 | |
| SCHEMBL1505737 | 0.73 | GPR119 (0.50) | GPR119KITMMP13 | |
| SCHEMBL1505850 | 0.72 | GPR119 (0.58) | GPR119MMP13KCNH2 | |
| SCHEMBL1505872 | 0.71 | GPR119 (0.46) | GPR119KITMMP13 | |
| SCHEMBL1505653 | 0.70 | PTPRZ1 (0.52) | GPR119KITMMP13KCNH2 | |
| SCHEMBL28927093 | 0.68 | CYP11B2 (0.62) | HTTKMT2AKITEGFRCYP11B2 | |
| SCHEMBL11478085 | 0.68 | ATM (0.47) | KMT2AKCNH2 | |
| SCHEMBL14538163 | 0.68 | POLB (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011030139-A1 | 4- (PYRIMIDIN-2-YL) -PIPERAZINE AND 4- (PYRIMIDIN-2-YL) -PIPERIDINE DERIVATIVES AS GPR119 MODULATORS | ASTRAZENECA AB (SE) | 2011-03-17 | — | — | WO | disclosed |