Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 1/20 | 0.42 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29958555 | 0.74 | CRHBP (0.38) | CRHBPCRHR2CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL4469191 | 0.73 | CRHBP (0.46) | KMT2AMEN1CRHBPCRHR2CYP2C19 | |
| SCHEMBL28331268 | 0.73 | KMT2A (0.42) | GABBR2GABBR1HSD17B10POLBSMN1; SMN2 | |
| Bromide SCHEMBL30297450 | 0.72 | CRHBP (0.44) | KMT2AMEN1CRHBPCRHR2CYP2C19 | |
| SCHEMBL30776869 | 0.71 | KMT2A (0.52) | HSD17B10KMT2AMEN1CRHBPCRHR2 | |
| SCHEMBL7592799 | 0.69 | CYP1A2 (0.71) | HSD17B10POLBSMN1; SMN2TDP1KMT2A | |
| SCHEMBL10973243 | 0.69 | KMT2A (0.47) | GABBR2GABBR1HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL9575031 | 0.68 | HSD17B10 (0.75) | GABBR2GABBR1HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL6689045 | 0.68 | ALDH1A1 (0.65) | HSD17B10POLBKMT2AMEN1HPGD | |
| SCHEMBL4855890 | 0.68 | CYP1A2 (0.74) | KMT2AMEN1CYP2C19CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794597-A1 | PYRIDINONE AND PYRIMIDINONE DERIVATIVES AS FACTOR XIA INHIBITORS | ONO Pharmaceutical Co., Ltd. (JP) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013093484-A1 | PYRIDINONE AND PYRIMIDINONE DERIVATIVES AS FACTOR XIA INHIBITORS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2013-06-27 | — | — | WO | disclosed |