Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.61 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5537147 | 0.85 | LTA4H (0.66) | MAOBBCHELTA4HEPHX2MGLL | |
| SCHEMBL15061331 | 0.85 | MAOB (0.66) | MAOBBCHEMAOADHFR | |
| SCHEMBL5544797 | 0.85 | IGF1R (0.47) | MAOBMAOALTA4HEPHX2 | |
| SCHEMBL15352211 | 0.84 | IGF1R (0.52) | MAOB | |
| SCHEMBL11353612 | 0.84 | IGF1R (0.52) | MAOB | |
| SCHEMBL9653036 | 0.84 | IGF1R (0.52) | MAOB | |
| SCHEMBL11146715 | 0.84 | IGF1R (0.52) | MAOB | |
| SCHEMBL1047259 | 0.84 | IGF1R (0.52) | MAOB | |
| SCHEMBL3890912 | 0.84 | IGF1R (0.52) | MAOB | |
| SCHEMBL15352069 | 0.84 | IGF1R (0.52) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476302-B2 | α-ketoamide derivatives useful endothelial lipase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-07-02 | — | — | US | claimed |