Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.66 |
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | RXRB | P28702 | 1/20 | 0.55 |
| ▸ | RXRG | P48443 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 3/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9627104 | 0.86 | MAOB (0.66) | MAOBRXRARXRBRXRGMAOA | |
| SCHEMBL15061343 | 0.85 | MAOB (0.61) | MAOBMAOADHFRBCHE | |
| SCHEMBL9626584 | 0.84 | LTA4H (0.68) | MAOBRXRARXRBRXRGMAOA | |
| SCHEMBL5537147 | 0.83 | LTA4H (0.66) | MAOBBCHE | |
| SCHEMBL1047871 | 0.83 | HTR3E (0.56) | — | |
| SCHEMBL15061376 | 0.83 | MAOB (0.68) | MAOBMAOA | |
| SCHEMBL9626463 | 0.82 | MAOB (0.64) | MAOBRXRARXRBRXRGMAOA | |
| SCHEMBL5539557 | 0.82 | LTA4H (0.68) | MAOBBCHE | |
| SCHEMBL15061297 | 0.81 | LPAR1 (0.47) | MAOB | |
| SCHEMBL3030471 | 0.81 | HTR3E (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476302-B2 | α-ketoamide derivatives useful endothelial lipase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-07-02 | — | — | US | claimed |