Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HMOX1 | P09601 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796893 | 0.87 | F2 (0.54) | F2KCNH2GRIN2BEPHX2LTA4H | |
| SCHEMBL5537147 | 0.84 | LTA4H (0.66) | EPHX2LTA4HMGLLBCHE | |
| SCHEMBL8573859 | 0.83 | HRH1 (0.63) | HRH1NPC1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL16289702 | 0.83 | HRH1 (0.63) | HRH1NPC1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL863724 | 0.83 | HRH1 (0.63) | HRH1NPC1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL8567865 | 0.83 | HRH1 (0.63) | HRH1NPC1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL23642807 | 0.83 | EPHX2 (0.64) | F2KCNH2GRIN2BEPHX2LTA4H | |
| SCHEMBL15061245 | 0.83 | APP (0.56) | BCHENPC1SMN1; SMN2 | |
| SCHEMBL15061351 | 0.83 | MAOB (0.59) | EPHX2LTA4HMGLLBCHE | |
| SCHEMBL15061343 | 0.83 | MAOB (0.61) | EPHX2LTA4HMGLLBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476302-B2 | α-ketoamide derivatives useful endothelial lipase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-07-02 | — | — | US | claimed |